A scientific diagram showing a cell membrane with water molecules moving through it, illustrating hydrophobic and hydrophilic regions, with an emphasis on hydrophobicity.

Polymer Nanodisc Products

The BzAM™ Terpolymer Series

Engineered to elevate your research with next-generation nanodisc technology.

  • Tradename - BzAM™ and/or SMALP BZ

    The use of the poly(styrene-co-maleic acid-co-X%(N-benzyl)maleimide) copolymers enables 100% detergent-free stabilization of membrane proteins. These polymers act like molecular "cookie cutters," facilitating direct membrane solubilization and stabilization in a single step directly from the cell membrane, while preserving proteins in a near-native lipid environment.

    Nanosene’s BzAM™, produced through advanced polymerization techniques, is a well-defined polymer with a molecular weight (Mw) of 5,500 g/mol and a low dispersity (narrow chain length distribution), a significant improvement over previous SMALPs. The BzAM™ series (BzAM25 / BzAM30 / BzAM35 / BzAM40) is a highly tunable series of polymers designed for systematic and methodical research. This series enables researchers to screen for their target protein before scaling up their assay and to investigate structure-activity relationships across various protein types and membrane systems.

    One of the most exciting features of the new BzAM™ polymers is the unique tunable platform they provide for investigating polymer amphiphilicity in target protein extraction. Research has shown that not all polymers are effective for all protein types, and this series enables the evaluation of the amphiphilic parameters required for optimal protein solubilisation from different membrane environments.

    This product is compatible with various phospholipid types, including saturated lipids, e.g., 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), and unsaturated lipids, e.g., 1-palmitoyl-2-oleoyl-glycero-3-phosphocholine (POPC).

    The BzAM™-membrane protein complex is suitable for a wide range of biophysical assays, including SDS-PAGE, SEC, Western blot, UV/Vis spectroscopy, and various chromatographic techniques, while compatible with affinity purification strategies.

  • Disclaimer:

    Tradename - BzAM™ and/or SMALP BZ

    Research Use Only – Patent Protected
    BzAM™ polymers are protected by issued and pending patent rights and are licensed exclusively to Nanosene. Purchase grants a limited, non-transferable right to use the product solely for internal research and development, including membrane protein solubilisation, purification, stabilization, screening, functional characterization, and related exploratory scientific applications.

    Use in humans or animals for therapeutic, diagnostic, or prophylactic purposes is strictly prohibited.

    Products may not be manufactured, distributed, resold, or used commercially without a separate written agreement.
    All rights not expressly granted are reserved.

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Highly tuneable series of polymers, allowing for systematic methodical research

Figure 1: (A) DLS particle size distribution of BzAM30 showing a sharp peak around 10 nm. (B) Negative-stain TEM micrograph of BZAM30-stabilized DMPC nanodiscs with a scale bar of 100 nm, with an inset showing a magnified view.
Western blot image showing protein bands around 75 kDa for mammalian cells, with lanes labeled BzAM125, BzAM130, BzAM135, BzAM140, and M (control).
Western blot image showing bands for His-tagged Family A GPCR expressed in bacterial cells (E. coli). Lanes labeled BzAM25, BzAM30, BzAM35, BzAM40, with a marker lane 'M' on the right. The molecular weight markers on the left are 100 kDa and 70 kDa.

Order the BzAM™ / SMALP BZ Screening Kit

Rapidly screen and identify the best BzAM™ / SMALP BZ polymer for your protein target, with robustly developed, precision-engineered copolymers and datasheets at your fingertips.

SMALP BZ Screening Kit (4x3x50 mg)

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  • RAFT Polymerization Technology

  • Ready-to-use

  • Multiple Formulations for Screening

  • Precision-Engineered with Low Dispersity

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